CovidV2, new, Analysis, bibRecord, 000815

Potential role of viruses in neurodegeneration

Identifieur interne : 000815 ( new/Analysis ); précédent : 000814; suivant : 000816

Potential role of viruses in neurodegeneration

Auteurs : Krister Kristensson [Suède]

Source :

Molecular and Chemical Neuropathology [ 1044-7393 ] ; 1992-02-01.

RBID : ISTEX:EC685A5B461C6C90814A8564281F42945A4BE9ED

English descriptors

KwdEn :
- ALS, Alzheimer’s disease, Creutzfeldt-Jakob’s disease, Gerstmann-Sträussler-Scheinker syndrome, Parkinson’s disease, Virus, calcium, cytoskeleton, excitotoxic amino acids, glutamate, immunologic tolerance, lipids, membranes, motor neuron disease, nervous system, neurodegenerative diseases, prion, protein synthesis, virus.

Abstract

Abstract: Viruses have the capacity to induce alterations and degenerations of neurons by different direct and indirect mechanisms. In the review, we have focused on some examples that may provide new avenues for treatment or altering the course of infections, i.e., antibodies to fusogenic virus membrane proteins, drugs that interfere with lipid metabolism, calcium channel blockers, immunoregulatory molecules, and, and inhibitors of excitotoxic amino acids. Owing to their selectivity in attack on regions of nervous tissue, governed by viral factors and by routes of invasion, viral receptors or metabolic machineries of infected cells, certain viral infections show similarities in distribution of their resulting lesions in the nervous system to that of the common human neurodegenerative diseases (namely, motor neurons disease, Parkinson’s disease, and Alzheimer’s disease). However, it should be emphasized that no infectious agent has as yet provided a complete animal model for any of these diseases, nor has any infectious agent been linked to them from observations on clinical or postomortem materials.

Url:

DOI: 10.1007/BF03159960

Affiliations:

Suède

Links to Exploration step

ISTEX:EC685A5B461C6C90814A8564281F42945A4BE9ED

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: Viruses have the capacity to induce alterations and degenerations of neurons by different direct and indirect mechanisms. In the review, we have focused on some examples that may provide new avenues for treatment or altering the course of infections, i.e., antibodies to fusogenic virus membrane proteins, drugs that interfere with lipid metabolism, calcium channel blockers, immunoregulatory molecules, and, and inhibitors of excitotoxic amino acids. Owing to their selectivity in attack on regions of nervous tissue, governed by viral factors and by routes of invasion, viral receptors or metabolic machineries of infected cells, certain viral infections show similarities in distribution of their resulting lesions in the nervous system to that of the common human neurodegenerative diseases (namely, motor neurons disease, Parkinson’s disease, and Alzheimer’s disease). However, it should be emphasized that no infectious agent has as yet provided a complete animal model for any of these diseases, nor has any infectious agent been linked to them from observations on clinical or postomortem materials.</div>
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Potential role of viruses in neurodegeneration

Potential role of viruses in neurodegeneration

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration Covid (26 mars)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.